Plasminogen Activators Potentiate Thrombin-Induced Brain Injury
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چکیده
منابع مشابه
Plasminogen activators potentiate thrombin-induced brain injury.
BACKGROUND AND PURPOSE Evidence suggests that cerebral edema following intracerebral hemorrhage (i.c.h.) results from a mass effect in combination with neurotoxic injury from clot-derived substrates such as thrombin. Thrombolytics can compete for thrombin inhibitors endogenous to the brain. This study examines the effect of intracerebral infusion of thrombolytics, tissue plasminogen activator (...
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Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available. Delayed bleeding is often ascribed to consumptive coagulopathy initiated by exposed brain tissue factor. We examined an alternative hypothesis, namely, that marked release of tissue-type plasminogen activator (tPA) followed by delayed...
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ژورنال
عنوان ژورنال: Stroke
سال: 1998
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.29.6.1202